Cardarine : The Complete Guide to this Strong SARM


Cardarine is also called GW501516. It is a drug developed in 1992 by joint research done by Glaxo Smith Kline and Ligand Pharmaceuticals. The drug was at first introduced in the market for its remarkable ability to reduce the risk to dyslipidemia and related disorders like atherosclerosis. The drug became popular when it started being by sportsmen and among athletes for its exceptional boost of strength and enhancement of endurance.

Metabolism problems caused by modern lifestyles and leading to more chronic problems like diabetes, heart disease, and inflammation led researchers to look for substances to speed up burning of fat burning and increase physical endurance. The researchers turned to the PPAR-delta and that is how Cardarine was discovered. Activating the PPAR-delta increases energy, muscle building, enhances endurance, and decreases lipids levels in the blood and speeds fat burning. Cardarine attaches itself and activates PPAR-delta (the peroxisome proliferator activator receptor delta).

Cardarine is PPAR agonists. PPAR stands for peroxisome proliferator-activated receptor. They activate the muscles androgen receptors. PPAR is similar to SARMs (selective androgen receptor modulators). These receptors increase insulin sensitivity which in turn increases the uptake of glucose and amino acids into skeletal muscles. The increased intake of glucose and amino acids leads to increased muscle growth and muscle hypertrophy as proteins are synthesized in the body. The PPAR are involved in the initiation of genetic channels through which energy used in exercises is activated.


  • The drug has a high bioavailability, meaning the body readily absorbs so even a small dose is sufficient enough to give the desired performance.
  • Helps the body to stop the synthesis of Fatty Acid
  • Cardarine is a non-stimulant, hence doesn’t come with fatigue or anxiety.
  • Cardarine is non-toxic and does not have adverse effects on important organs.
  • It does not lead to the development of its tolerance like SARMs, hence no need for post cycle therapy.
  • The drug is non-estrogenic
  • GW501516 can be used with other endurance enhancing drugs or SARMs to increase the performance.
  • It boosts recovery and also elevates the mood hence allowing athletes to train harder and for longer periods.
  • Cardarine improves the levels of HDL (good cholesterol) and decreases the levels of LDL (bad cholesterol)
  • Cardarine boosts metabolism, prevent obesity, improves fat burning, and increase muscle growth.
  • 1Cardarine suppresses inflammation in many cases, therefore, it is anti-inflammatory and antioxidant.


During the research, cancer incidences have been reported in mice but there has not been a case reported in humans.

  • Cardarine is not legal, nor is it approved for use in humans.
  • It is only available as a research substance and can only be bought on the black market.
  • It is recorded in the World Anti-Doping Agency, therefore, termed as cheat or toxicity for athletes.
  • In research, Cardarine increased the death of the liver cells and thus caused liver damage in mice.


Cardarine remarkably works on many aspects of the body but like other drugs, the intake must be monitored.

Per day use an average dose of 10 to 20 mg for 8 to 12 weeks with breaks of 4 to 6 weeks in between.

Cardarine can be used with SARMs like Ostarine for better results.


The uses of Cardarine are discussed on the areas they affect [positively on the human body when taken. Most of the uses are based on research done on animals.

1) Brain

In a study on animals, Cardarine protected the brain vessels from damage, oxidative stress and helped to maintain normal blood flow in the brain. Cardarine itself has not been tested on humans, but PPAR activators are known to boost the development of brain nerve cells. Cardarine effect on inflamed brain cells of a rat were both pro- and anti-inflammatory. It is not clear if Cardarine can protect the brain or if it can bring any damages.

2) Preventing Obesity

By increasing the rate of fat burning and growth of muscles Cardarine activates PPAR delta and prevents the activity of inflammatory substances in fat tissue, which aids obesity and chronic inflammation. In research done on obese monkeys, the drug increased HDL (good cholesterol) and decreased LDL (bad cholesterol), decreased triglycerides, and insulin. It prevents the release of too much glucose by the liver. These are helpful in preventing obesity.

3) Fat-Burning

Initially, Cardarine was researched for burning fats. Recent, studies have shown the benefits of Cardarine in fat-burning and increasing energy use. In one research study done with 13 men with bad cholesterol and belly fat Cardarine decreased fatty acids and triglycerides, and VLDL proteins.

4) Heart and blood vessels

Cardarine is known to regulate cholesterol, which affects the heart and the blood vessels. It prevents oxidative damages to the blood vessels in mice that were used in research. Cardarine reduces the risk of arteries having plaque buildup as it increases the levels of nitric oxide which is protective to the blood vessel. Cardarine also helps clear the blood vessels and this reduces the risks of heart diseases and other related complications.

5) Kidneys

In a research study done on mice, Cardarine lowered kidney inflammation. This suggests Cardarine protect the kidney against diseases.

7) Prevents liver damage

The liver is important in the body for storing, releasing and burning fats hence a top target for Cardarine. It facilitates the liver to use fatty acids as a source of its energy instead of normal glucose. This reduces blood sugar and prevents liver damage.

8) Stamina and muscle growth

By activating PPAR-delta, Cardarine starts the development of muscle fibers as seen in a study conducted on mice. The development of muscle fibers increases stamina and physical performance in humans.

9. Used in sports

Cardarine is used in sports training as it enhances endurance, improves, performances and stamina. It also helps in quick recovery and improves the body’s overall productivity.

10. Metabolism and metabolic disorders

Development of Cardarine can be used in medicine to enhance body metabolism. It promotes conversion and breakdown of stored fat to energy. This ensures that it prevents disorders that arise from metabolic problems.


Cardarine has very many positive uses in the body and not may its side effects have been reported. This means that it is a promising drug and can have better medical outcomes when taken in the correct dosage and for the correct purpose. Cardarine may not be readily available in the market due to doping regulations in some countries like the UK where it is illegal but it is available in most countries which have not scheduled it as either legal or illegal. There are also natural ways that can be used to activate PPAR-delta in the body apart from Cardarine. You can intake Cardarine for more endurance in exercises, and training however, it is banned for professional athletes worldwide because of the competitive benefits it offers. Medically the drug can be used.